Senior Research Scientist and University of Alberta alumnus with over 15 years of advanced research
experience. Expertise lies at the intersection of biomolecular condensates, endogenous retroelem…
Senior Research Scientist and University of Alberta alumnus with over 15 years of advanced research
experience. Expertise lies at the intersection of biomolecular condensates, endogenous retroelement
(LINE-1) regulation, and the DNA Damage Response (DDR). Developer of the "Condensate Checkpoint"
model linking phase-separated condensates to cGAS/STING innate immunity. Possesses extensive
experience in protein purification from stable cell lines, advanced microscopy (smFISH, TEM), and
CRISPR genome editing. Proven track record in research publication, grant writing, trainee mentorship,
and cross-team scientific collaboration.
Construct stable mammalian cell lines (U2OS, HEK 293T) for the purification and characterization of complex ribonucleoprotein assemblies (AGO2 complexes) for structural and biochemical analysis.
Investigated AGO2-RISC assembly via molecular chaperones.
Studied the mechanism of Ago2 in promoting the translation of ST6GAL1.
Mentored graduate students and assisted undergraduates in experimental design, molecular biology techniques, and data analysis.
Construct stable mammalian cell lines (U2OS, HEK 293T) for the purification and characterization of complex ribonucleoprotein assemblies (AGO2 complexes) for structural and biochemical analysis., Investigated AGO2-RISC assembly via molecular chaperones., Studied the mechanism of Ago2 in promoting the translation of ST6GAL1., Mentored graduate students and assisted undergraduates in experimental design, molecular biology techniques, and data analysis.
Led projects investigating the regulation of endogenous human LINE-1 (L1hs) by Argonaute proteins (AGO1/AGO2) and small RNA pathways in nuclear and cytoplasmic condensates.
Developed the "Condensate Checkpoint" model and established cellular/biochemical assays to detect checkpoint breaching and quantify downstream cGAS/STING pathway activation.
Investigated the spatial organization of biomolecular condensates (Stress Granules, Processing Bodies, DDR foci) and their role in regulating endogenous nucleic acid metabolism and innate immunity.
Studied the intersection of genome instability, PARylation, and chromatin silencing at DNA double-strand breaks (DSBs).
Constructed stable mammalian cell lines (U2OS) for the purification and characterization of large, complex ribonucleoprotein assemblies (Ago1/Ago2 complexes) for structural and biochemical analysis.
Co-developed and drafted a successful CIHR grant application in collaboration with Dr. Michael Hendzel.
Mentored graduate students and assisted undergraduates in experimental design, molecular biology techniques, and data analysis.
Led projects investigating the regulation of endogenous human LINE-1 (L1hs) by Argonaute proteins (AGO1/AGO2) and small RNA pathways in nuclear and cytoplasmic condensates., Develop the "Condensate Checkpoint" model and establish cellular/biochemical assays to detect checkpoint breaching and quantify downstream cGAS/STING pathway activation., Investigate the spatial organization of biomolecular condensates (Stress Granules, Processing Bodies, DDR foci) and their role in regulating endogenous nucleic acid metabolism and innate immunity., Studied the intersection of genome instability, PARylation, and chromatin silencing at DNA double-strand breaks (DSBs)., Construct stable mammalian cell lines (U2OS) for the purification and characterization of large, complex ribonucleoprotein assemblies (Ago1/Ago2 complexes) for structural and biochemical analysis., Co-developed and drafted a successful CIHR grant application in collaboration with Dr. Michael Hendzel., Mentored graduate students and assisted undergraduates in experimental design, molecular biology techniques, and data analysis.
Investigated the molecular mechanisms of germline stem cell regulation, niche occupancy, and piRNA/siRNA and miRNA biogenesis in Drosophila.
Established expertise in small RNA pathways, stem cell tumor formation, and advanced genetic screening.
Investigated the molecular mechanisms of germline stem cell regulation, niche occupancy, and piRNA/siRNA and miRNA biogenesis in Drosophila., Established expertise in small RNA pathways, stem cell tumor formation, and advanced genetic screening.
Investigated the molecular mechanisms of germline stem cell regulation, niche occupancy in Drosophila.
Established expertise in stem cell biology, stem cell tumor formation, and advanced genetic screening.
Investigated the molecular mechanisms of germline stem cell regulation, niche occupancy in Drosophila., Established expertise in stem cell biology, stem cell tumor formation, and advanced genetic screening.
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