Principal ScientistDirector Chemical Biology

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
• Experiencing leading and managing highly effective teams in the industry.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Strong experience with:
  • Hit finding and hit-to-lead studies
  • HTS and phenotypic assay development and screening
  • Small molecule binding affinity assays
  • PPI techniques, e.g., BRET, APEX/BioID, AlphaScreen
• Proficiency in:
  • Platform development
  • Compound management
  • Disease model development
  • Biochemical assay development
• Nice to have:
  • Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc
  • Familiarity or experience with PROTAC/next-gen IPM technologies
  • Biophysical screening techniques such as SPR or fluorescence anisotropy
  • DEL experience
  • Experience with med-chem optimizations: SAR, PK/PD, etc
  • Computational drug discovery experience
  • Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
• Reading budget! We will buy you books.
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.