Description

The Jo Van Ginderachter (JVG) lab is looking for an outstanding postdoctoral scientist interested in understanding how the heterogeneity and pro-tumoral activity of tumor-associated macrophages is regulated and how the manipulation of such regulatory mechanisms can be harnessed to improve immunotherapy. We are especially interested in understanding how RNA epigenetic alterations sculpt tumor-associated macrophages and affect the tumor-promoting function of these cells in various mouse models of non-small cell lung carcinoma and triple-negative breast cancer, as well as their human

This project is embedded within a high profile, excellence-based research consortium (EOS program) of four partners in Belgium (Jo Van Ginderachter-VIB/Vrije Universiteit Brussel, Massimiliano Mazzone-VIB/KULeuven, Pierre Close-Universit de Li ge and Fran ois Fuks-Universit Libre de Bruxelles). While the JVG and MM labs are at the forefront of tumor-associated macrophage research, PC and FF are renowned experts on RNA The postdoctoral scientist will be actively involved in this consortium and will interact and collaborate with the partner

The project relies on cutting-edge technologies such as single-cell RNA sequencing, CITE-Seq, high-dimensional cytometry, spatial transcriptomics, and mouse genetic models. In addition, this project is further supported by a student and a dedicated bio-informatician in the JVG

The JVG lab is located at the Science/Humanities campus of the Vrije Universiteit Brussel, in the center of Brussels and in the heart of Europe, and is part of the excellence-based VIB Center for Inflammation Research (director: Bart Lambrecht).

Selected references:

Geeraerts X, Fernandez-Garcia J, …, Van den Bossche J*, Fendt SM*, Van Ginderachter JA*. *Equal Macrophages are metabolically heterogeneous within the tumor Cell Reports 2021, doi:

Pombo Antunes AR, Scheyltjens I, Ginderachter JA*, Movahedi K*. *Equal Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and Nature Neuroscience 2021, doi:

Van Damme H, …, Laoui D*, Van Ginderachter JA*. *Equal Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 Journal for Immunotherapy of Cancer 2021, doi:

Bieniasz-Krzywiec P, …, Van Ginderachter JA, Mazzone Podoplanin-expressing macrophages promote lymphangiogenesis and lymphoinvasion in breast Cell Metabolism 2019, doi:

Laoui D, Keirsse J, , Van Ginderachter The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour Nature Communications doi:

Profile

• in biology, bio-engineering sciences, medical sciences, biomedical sciences, or related
• Solid publication record
• Experienced in immunology, preferably myeloid cell
• Experienced in working with mouse models (FELASA B or C required).
• Experience with flow cytometry and single-cell -omics is highly beneficial
• Experience in tumor immunology is
• Excellent spoken and written English skills
• Creative, highly motivated, independent, team player

We offer

• The possibility to independently lead your research project, but with sufficient guidance and
• Excellent training conditions, with the possibility to learn a wide set of cutting-edge
• A friendly, dynamic, and scientifically stimulating working environment, with a team of highly motivated
• Long-term career
• Funding for up to 4 However, you will be encouraged to also apply for personal

Starting date: as soon as

How to apply?

• A detailed CV, containing a full list of publications
• Motivation letter
• Summary of past research
• Names and contact information of 2-3 referees

For additional information on the position contact Jo Van Ginderachter ()